1. Ears and auditory^5,6

GPA>MPA

Hearing loss, earache

2. Eyes^5,6

GPA>>MPA

Red, painful eyes

3. Nose and sinuses^3,5,6

GPA>>MPA

Saddle nose deformity, nasal septum deformity, sinusitis

4. Skin^3,6

GPA>MPA

Rashes, purpura, lesions

5. Lungs and upper airways^3,5-7

GPA>MPA

Coughing, pain, lung nodules (seen in X rays), alveolar haemorrhage

6. Nervous system^3,5,6

CNS (GPA=MPA), PNS (MPA>GPA)

Mononeuritis, paraesthesia, other peripheral neuropathy

7. Kidneys^5,6

MPA>GPA

Blood in the urine

8. QoL impairment8

Similar to other chronic diseases and includes anxiety, fatigue, sleep disturbance, depression and pain